Here’s
some potentially good news from Ryan Cross who wrote about Alexandre
Carpentier (pictured above), a neurosurgeon at the Pitié-Salpêtrière Hospital in Paris, who used
“ultrasound to open the blood-brain barrier in patients with recurrent
glioblastoma, the most common and deadly tumor originating in the adult
brain—allowing for delivery of chemotherapy that would otherwise reach the
tumor in minuscule amounts” - https://www.technologyreview.com/s/601691/ultrasound-opens-the-brain-to-promising-drugs/
As
background, you should know that the protective sheath surrounding the brain’s
blood supply—known as the blood-brain barrier—is a safeguard against nasty
germs and toxins. But it also prevents existing drugs that could potentially be
used to treat brain cancer or Alzheimer’s disease from reaching the brain.
According
to Cross, “the procedure works by first injecting microbubbles into the
bloodstream and then using a device implanted near patients’ tumors to send
ultrasonic soundwaves into the brain, exciting the bubbles. The physical
pressure of the bubbles pushing on the cells temporarily opens the blood-brain
barrier, letting an injected drug cross into the brain.”
Here’s a link to the abstract: http://stm.sciencemag.org/content/8/343/343re2
Picture: Alexandre Carpentier holds the SonoCloud device, which he has implanted in 15 brain cancer patients.
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