I
just read the “Precision Medicine Conference” highlights posted on the National
Brain Tumor Society website: http://blog.braintumor.org/precision-medicine-conference-highlights/
and found myself hopeful, if confused.
I’m
hopeful because the highlights sound surprisingly upbeat, positive and, well,
optimistic. Why? Because (as best I can tell) we are starting to really
leverage our understanding of the human genome as it relates to more effectively treating brain tumors.
Dr.
Jennifer Helfer, PhD, explains this much more clearly in her conference recap by stating that “Precision
medicine, also referred to as personalized or individualized medicine, is
defined on Wikipedia as ‘a medical model that proposes the customization of
healthcare—with medical decisions, practices, and/or products being tailored to
the individual patient.’"
Part
of this introductory statement is still confusing to me – why is the idea of “medical
decisions, practices and/or products being tailored to the individual patient”
a radical/newsworthy idea? Haven’t we always been doing that? If not, why not?
As best I can tell, some
of this stems from the importance of an individual victim's genetics in addition to the tumor's classification, e.g. glioblastoma. Being able to research this linkage, according to Dr. Jeffrey Flier, Dean of the Harvard Medical School, is being led - somewhat strangely - by patients who are “collecting and sharing their own medical
information via sites like 23andMe" - https://www.23andme.com/
This
information appears to give medical professionals better direction on how to
treat patients’ individual and unique brain tumors. The challenge, it appears,
is that more doctors need to become more familiar with this information in order to
administer and interpret this genetic information.
If
you do nothing else, watch this video entitled “Discovering the PD-1
Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology” - https://www.youtube.com/watch?v=B532URzuJOU
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